Change Bio

Design

Rapid, reliable protein expression in your own lab.

nsure takes a sequence to an expressing strain in a week. Build and screen libraries in K. phaffii for the first time.

Beta cohort. 5 of 10 spaces remaining.

The problem

Strain construction in K. phaffii is slow and unreliable. Most workflows test one sequence at a time. For protein engineers running design-build-test cycles, this is the bottleneck that decides how fast you can iterate.

What nsure does

nsure replaces conventional transformation and selection methods with a proprietary platform engineered for speed and throughput. You get:

  • Sequence to expressing strain in as little as a week
  • Library construction and screening in K. phaffii, for the first time
  • Hundreds to thousands of sequences per run, where current methods test one

Pair with pooled library screening

Want to screen larger libraries than your lab can run? Our pooled library screening service, launching September 2026, ranks candidates by manufacturability under production-representative conditions. It pairs naturally with libraries built using nsure.

Beta cohort

The beta cohort gives you early access to the nsure platform in exchange for feedback that shapes the product. Beta testers receive technical support directly from the Change Bio team.

5 spaces remain.

Apply for the beta